WAYRILZ: Real Stories That Inspire

Onscreen Text: WHAT IS WAYRILZ? WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough. It is not known if WAYRILZ is safe and effective in children. Please see full Important Safety Information at the end of the video.

JoBeth: Hi, my name is JoBeth.
Onscreen Text: JOBETH living with ITP
ITP=immune thrombocytopenia.

JoBeth: For me, being able to do tap or jazz, it's a nice break…
Onscreen Text: JoBeth has been compensated by Sanofi to share her story.

JoBeth: …from reality, from my job, from managing my rare disease, any other responsibilities.

JoBeth: We were in the middle of COVID whenever my symptoms started appearing. And so, I waited for some time before actually going to the doctor.

JoBeth: I would wake up and there would be bruises the size of grapefruits on the inside of my calf or the back of my arm. And I would think to myself, “Oh, I don't remember hitting the back of my arm.”

JoBeth: Nosebleeds started small as well. The last one that I had lasted 2 and a half hours. But after that nosebleed, the fatigue was so severe. It was really a challenge.

I knew that it wasn't normal to sleep 8 or 9 hours and wake up feeling like I had slept less than a minute.

JoBeth: So, I went to see my doctor. We did some blood work.

JoBeth: And my doctor said, um, “Your blood work came, came back, and showed that you have a very low platelet count.” I think the number might have been 7,000 at that point, with the normal range being between 150,000 and 400,000.

JoBeth: My experience with managing ITP was challenging, for sure.

JoBeth: A lot of my social life ended because I was too tired.

JoBeth: I was very unstable and not knowing when I was going to have to have a rescue treatment, when I was going to end up in the hospital for 2 or 3 days at a time.

JoBeth: I did have to really limit my social activities and engagements.

JoBeth: I did have tears when I had to stop dancing because I love it so much.

JoBeth: But, ITP is not just a physical disease. It definitely impacts people emotionally and mentally. I sometimes found that to be a bigger challenge than the physical ailments that were coming from the disease.

JoBeth: Eventually, I just got to the point where I started carrying a bag with me. I left that bag in my car at all times.

JoBeth: And every Tuesday I would go in and have the blood draw, and, hopefully, I would get to go to work.

JoBeth: And if I didn't, then I would walk out to my car and get my bag and walk upstairs in the hospital and get checked in and settled into a room.

JoBeth: There was so much unsure-ity around it.

JoBeth: I was always just waiting for the other shoe to drop.

JoBeth: I was seeing my doctor for my annual visit, and she mentioned that…

JoBeth: …WAYRILZ may be an option available for my ITP. My mother was along with me on that appointment.
Onscreen Text: WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough.

JoBeth: When she introduced us to the concept of WAYRILZ, we wanted to understand better how it worked and why it would be a treatment plan for me.

JoBeth: And so, we started asking some questions around the medicine and how it worked, and she explained that it was very targeted.

JoBeth: My doctor explained the risks and the benefits. I just was very excited leaving her office that day.
Onscreen Text: The most common side effects of WAYRILZ include diarrhea, nausea, headache, stomach area (abdominal) pain, and COVID-19.

JoBeth: My doctor and I have noticed since starting WAYRILZ that my platelet count is remaining stable. We’re able to meet our objective and our goal…
Onscreen Text: During the last 12 weeks of the study, 23% of people taking WAYRILZ (vs 0% of those who did not) reached a platelet level of 50,000 or higher more than 5 times when measured weekly, without rescue therapy, including at least twice in the final 6 weeks.

JoBeth: of 100,000 consistently.

JoBeth: I’ve been on WAYRILZ for 9 months now. My platelet count was stable enough…
Onscreen Text: WAYRILZ is a 400-mg pill taken twice daily.

JoBeth: …on WAYRILZ that I made the decision to take my hospital bag out of my car.

JoBeth: I was afraid I was going to jinx myself, but I was brave enough to remove it from the car and had so much joy in doing that.

JoBeth: When I unpacked the bag, the weight of the anxiety that I was carrying lifted off of my shoulders.

JoBeth: I've experienced minimal side effects with the medicine...
Onscreen Text: This is JoBeth's personal experience. Your results may vary.

JoBeth: ...and I'm very thankful of that.


JoBeth: I would describe how I feel these days as myself but with better perspective.

JoBeth: Being more stable has allowed me to free up some time to return to doing a lot of the things that I love to do like baking, dancing, piano playing, and visiting with friends and family.

JoBeth: That is part of why I advocate so much in the rare disease space—being able to connect to other families, anybody that is having the same or similar experience that I'm walking through.

JoBeth: Being able to give people hope—I think, extremely important as they're navigating their own walk.

IMPORTANT SAFETY INFORMATION

What should I tell my healthcare provider before taking WAYRILZ?

Tell your healthcare provider about all of your medical conditions, including if you:

• have liver problems
• have kidney problems
• are pregnant or plan to become pregnant. WAYRILZ may harm your unborn baby. If you are able to have a baby, your healthcare provider will do a pregnancy test before starting treatment with WAYRILZ. Females who are able to become pregnant should use an effective birth control during treatment with WAYRILZ and for 1 week after the last dose.
• are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with WAYRILZ and for at least 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking WAYRILZ with certain other medicines may affect how WAYRILZ works and can cause side effects. WAYRILZ may also affect how other medicines work.

What should I avoid while taking WAYRILZ?

You should avoid grapefruit, starfruit and products that have these fruits, and Seville oranges (often used in marmalades) during treatment with WAYRILZ. These products may increase the amount of WAYRILZ in your blood, which increases the risk of side effects of WAYRILZ.

What are the possible side effects of WAYRILZ?

WAYRILZ may cause serious side effects, including:

• Serious infections. WAYRILZ can increase the risk of infections, including serious infections that can lead to death. Your healthcare provider will check you for signs and symptoms of infection during your treatment with WAYRILZ. Tell your healthcare provider right away if you get any signs or symptoms of infection, including fever, chills, or flu-like symptoms.
• Liver problems including Drug-Induced Liver Injury (DILI). Liver problems, which may be severe, life-threatening, or lead to death have happened in people treated with Bruton’s tyrosine kinase (BTK) inhibitors. Your healthcare provider will do blood tests to check your liver before and as necessary during treatment with WAYRILZ. Tell your healthcare provider right away if you have any signs or symptoms of liver problems, including stomach-area (abdominal) pain or discomfort, dark or “tea-colored” urine, or yellowing of the skin or the white part of your eyes.

The most common side effects of WAYRILZ include diarrhea, nausea, headache, stomach area (abdominal) pain, and COVID-19.

These are not all of the possible side effects of WAYRILZ.

WHAT IS WAYRILZ?

WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough.

It is not known if WAYRILZ is safe and effective in children.

Please see accompanying full Prescribing Information, including Patient Information.

Leigh Anne: My name is Leigh Anne, and ITP is part of my story. But it is not my whole story.

Leigh Anne: I think I did brush off a lot of signs and symptoms…
Onscreen Text: What is WAYRILZ?
WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough. It is not known if WAYRILZ is safe and effective in children. Please see full Important Safety Information at the end of the video.

Leigh Anne: …in the beginning. I was a new mom…
Onscreen Text: LEIGH ANNE living with ITP
ITP=immune thrombocytopenia.

Leigh Anne: and you're just tired in that postpartum period.
Onscreen Text: Leigh Anne has been compensated by Sanofi to share her story.

Leigh Anne: I'm also quite a klutz. I do walk into things all the time, specifically my bed frame, so I would always have bruises on my upper hips and outer thighs.

Leigh Anne: I frequently would have broken blood vessels underneath my fingernails and around my cuticles. And again, I just blew that off as a symptom of my aggressive nail biting. One of the biggest signs and symptoms that I had was bleeding when having a bowel movement.

Leigh Anne: In the early days, it was a lot of appointments at my hematologist. Each week I would go to get my blood count checked, which includes my platelet check, and just the anxiety of sitting in the parking lot waiting to go in, wondering what that number would be.

Leigh Anne: It really was a roller coaster, up and down with the platelet number. ITP has affected me physically, first and foremost through the bruising and the bleeding, being asked by friends and family, “Oh, did you walk into something?”

Leigh Anne: I think the hardest part of living with ITP is the fatigue. It comes and goes. There's no rhyme or reason to it.

Leigh Anne: I felt like I was disappointing myself and others by not being as active as I could be. The other moms are out there playing with their sons, and I'm just so exhausted.

Leigh Anne: My first hematologist and I really focused on the numbers. And that guided my treatment in the first years.

Leigh Anne: We did not really discuss long-term goals.

Leigh Anne: I feel like one of the largest challenges was jumping from treatment to treatment. If something wouldn't work, we would give it about six months, then we were back to square one. So that was very frustrating.

Leigh Anne: I think the thing I was looking forward to the most with trying a new medication was stability.

Leigh Anne: The greater picture is the platelet number, but I think over time it's become so much more than that. Reducing office visits, reducing blood work checks, becoming stable on a medication is more than just the numbers itself.

Leigh Anne: Soon after learning about…

Leigh Anne: WAYRILZ approval, I did call my hematologist’s office.
I said, “There's a medication that just got FDA approved.”
Onscreen Text: WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough.

Leigh Anne: I was already back at square one with my treatment plan. He called me right back.

Leigh Anne: We did discuss that it was a pill. It did not require…
Onscreen Text: WAYRILZ is a 400-mg pill taken twice daily.

Leigh Anne: …coming into the hematology office. You don't have to get blood work done beforehand.

Leigh Anne: My doctor did mention that, as with all medications, there are risks and benefits.
Onscreen Text: The most common side effects of WAYRILZ include diarrhea, nausea, headache, stomach area (abdominal) pain, and COVID-19.

Leigh Anne: He mentioned that we would keep a close eye on my liver labs, and that we would continue to check my blood work weekly during the onboarding period.
With WAYRILZ, after a month's time, we started to see that first increase and we were really happy. We see less fluctuations, less ups and downs…
Onscreen Text: During the last 12 weeks of the study, 23% of people taking WAYRILZ (vs 0% of those who did not) reached a platelet level of 50,000 or higher more than 5 times when measured weekly, without rescue therapy, including at least twice in the final 6 weeks.

Leigh Anne: …and more stability, which is really nice. I've not fallen into any critical zones. I have not needed any hospitalizations.

Leigh Anne: For reference, we try to be at 50,000 or higher.

Leigh Anne: But the great thing is that I have been in the 100,000s starting at that…
Onscreen Text: This is Leigh Anne’s personal experience. Your results may vary.

Leigh Anne: …second month being on WAYRILZ.

Leigh Anne: And we have actually increased the time in between appointments.

Leigh Anne: We now have about six weeks in between checks and visits, and he asks me more about how my day is. How has my fatigue been, my ability to eat and get stuff done around the house.

Leigh Anne: Now that I'm about nine months in, it's been really awesome to see that my platelets are remaining constant over time.

Leigh Anne: I am doing the things I like to do, such as gardening, being there for my son, going to his hockey games, making candles. I really do enjoy cooking, especially with my own vegetables.

Leigh Anne: I did have some challenges that were discussed with me and expected, but I had a lot of support not only from my physician, but the Sanofi HemAssist Nurse program to help me get over that hump.

Leigh Anne: I met my representative pretty early in the treatment.

Leigh Anne: We were aware that some of the risks with taking WAYRILZ included stomach upset and possible diarrhea.

Leigh Anne: She was very reassuring about the nausea and GI upset that I had in the beginning, and she's the one who suggested that taking the medication in the morning with breakfast would help reduce the nausea.

Leigh Anne: Over time, those symptoms did decrease. I'm really glad that I gave it a good effort and got over that hump because the stability came within a month's time or so.

Leigh Anne: She always gave me her number and that I was free to call her in addition to her calling me.

Leigh Anne: That level of communication really helped me to feel that I was not alone. I did not know any other individuals on WAYRILZ in my online community or in my local healthcare system. So I felt like I had a partner in this onboarding journey.

Leigh Anne: I have gone to Washington, D.C., to speak on Capitol Hill twice to advocate for patients. In that process, I've learned that all of our stories are different, yet there's a unique thread that we all share.

Leigh Anne: The biggest takeaway that I've gotten from this journey is that you are more than your number. You are an entire person with a life and a family and goals and things you need to do and accomplish. There’s a lot of hope in the future for people living with ITP.

IMPORTANT SAFETY INFORMATION

What should I tell my healthcare provider before taking WAYRILZ?

Tell your healthcare provider about all of your medical conditions, including if you:

• have liver problems
• have kidney problems
• are pregnant or plan to become pregnant. WAYRILZ may harm your unborn baby. If you are able to have a baby, your healthcare provider will do a pregnancy test before starting treatment with WAYRILZ. Females who are able to become pregnant should use an effective birth control during treatment with WAYRILZ and for 1 week after the last dose.
• are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with WAYRILZ and for at least 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking WAYRILZ with certain other medicines may affect how WAYRILZ works and can cause side effects. WAYRILZ may also affect how other medicines work.

What should I avoid while taking WAYRILZ?

You should avoid grapefruit, starfruit and products that have these fruits, and Seville oranges (often used in marmalades) during treatment with WAYRILZ. These products may increase the amount of WAYRILZ in your blood, which increases the risk of side effects of WAYRILZ.

What are the possible side effects of WAYRILZ?

WAYRILZ may cause serious side effects, including:

• Serious infections. WAYRILZ can increase the risk of infections, including serious infections that can lead to death. Your healthcare provider will check you for signs and symptoms of infection during your treatment with WAYRILZ. Tell your healthcare provider right away if you get any signs or symptoms of infection, including fever, chills, or flu-like symptoms.
• Liver problems including Drug-Induced Liver Injury (DILI). Liver problems, which may be severe, life-threatening, or lead to death have happened in people treated with Bruton’s tyrosine kinase (BTK) inhibitors. Your healthcare provider will do blood tests to check your liver before and as necessary during treatment with WAYRILZ. Tell your healthcare provider right away if you have any signs or symptoms of liver problems, including stomach-area (abdominal) pain or discomfort, dark or “tea-colored” urine, or yellowing of the skin or the white part of your eyes.

The most common side effects of WAYRILZ include diarrhea, nausea, headache, stomach area (abdominal) pain, and COVID-19.

These are not all of the possible side effects of WAYRILZ.

WHAT IS WAYRILZ?

WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough.

It is not known if WAYRILZ is safe and effective in children.

Please see accompanying full Prescribing Information, including Patient Information.