Designed to target key sources of ITP
In ITP, the immune system is out of balance and mistakenly attacks your platelets. A protein called Bruton's tyrosine kinase (BTK) plays a key role in sending signals that drive this imbalance.
WAYRILZ is a BTK inhibitor—it works by targeting those harmful signals at the source. In the medical community, this process is commonly referred to as immune modulation or multi-immune modulation.
What does this mean for your platelets?
WAYRILZ works in multiple ways to help protect platelets by:
Preventing autoantibodies from marking platelets for destruction
Stopping immune cells from attacking and breaking down platelets
Does WAYRILZ broadly suppress the immune system?
No, WAYRILZ does not broadly suppress the immune system. Instead WAYRILZ works by modulating specific immune cells in ITP.
WAYRILZ helps restore immune balance, which may allow your body to better protect and raise platelet counts.
A closer look at how WAYRILZ works
Dr. Koprivnikar explains how BTK is involved in the immune system’s attack on platelets, and why targeting BTK with WAYRILZ helps get to the source in multiple ways.
Understanding the science of ITP and how WAYRILZ fits in
Want to dive deeper into ITP and how WAYRILZ works? Explore the definitions below.
Antibody
A protein made by the immune system to help find and fight things that don’t belong in the body, like viruses or bacteria.
In a healthy immune system, antibodies help protect you from illness.
Autoantibody
A type of antibody that mistakenly targets the body’s own cells instead of harmful invaders.
In ITP, autoantibodies attach to platelets and mark them for destruction.
Bruton’s Tyrosine Kinase (BTK)
A protein within the immune system that helps regulate immune system activity.
In ITP, BTK plays a key role in fueling the overactive immune signals that lead to immune imbalance.
Immune Cell
A cell in the body that helps defend against infection.
In ITP, immune cells such as B cells and macrophages are key players in the immune attack on healthy platelets. B cells produce autoantibodies that mark platelets, and macrophages recognize and destroy those marked platelets.
Multi-Immune Modulation
The process of calming or adjusting immune system activity, so it is balanced rather than overactive or underactive.
In ITP, multi-immune modulation works by targeting multiple aspects of ITP to reduce harmful immune activity and restore immune balance.
Platelet
A type of blood cell that helps your body form clots to stop bleeding.
In ITP, platelet counts are low, so it can be harder for bleeding to stop.
WAYRILZ is a prescription medicine that is used to treat adults with persistent or chronic immune thrombocytopenia (ITP) who received a prior treatment that did not work well enough.
It is not known if WAYRILZ is safe and effective in children.
What should I tell my healthcare provider before taking WAYRILZ?
Tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems
- have kidney problems
- are pregnant or plan to become pregnant. WAYRILZ may harm your unborn baby. If you are able to have a baby, your healthcare provider will do a pregnancy test before starting treatment with WAYRILZ. Females who are able to become pregnant should use an effective birth control during treatment with WAYRILZ and for 1 week after the last dose.
- are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with WAYRILZ and for at least 1 week after the last dose.
Tell your healthcare provider about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Taking WAYRILZ with certain other medicines may affect how WAYRILZ works and can cause side effects. WAYRILZ may also affect how other medicines work.
What should I avoid while taking WAYRILZ?
You should avoid grapefruit, starfruit and products that have these fruits, and Seville oranges (often used in marmalades) during treatment with WAYRILZ. These products may increase the amount of WAYRILZ in your blood, which increases the risk of side effects of WAYRILZ.
What are the possible side effects of WAYRILZ?
WAYRILZ may cause serious side effects, including:
- Serious infections. WAYRILZ can increase the risk of infections, including serious infections that can lead to death. Your healthcare provider will check you for signs and symptoms of infection during your treatment with WAYRILZ. Tell your healthcare provider right away if you get any signs or symptoms of infection, including fever, chills, or flu-like symptoms.
- Liver problems including Drug-Induced Liver Injury (DILI). Liver problems, which may be severe, life-threatening, or lead to death have happened in people treated with Bruton’s tyrosine kinase (BTK) inhibitors. Your healthcare provider will do blood tests to check your liver before and as necessary during treatment with WAYRILZ. Tell your healthcare provider right away if you have any signs or symptoms of liver problems, including stomach-area (abdominal) pain or discomfort, dark or “tea-colored” urine, or yellowing of the skin or the white part of your eyes.
The most common side effects of WAYRILZ include diarrhea, nausea, headache, stomach area (abdominal) pain, and COVID-19.
These are not all of the possible side effects of WAYRILZ.
Please see full Prescribing Information, including Patient Information.
